Impact of process parameters in the generation of nanoemulsions containing omega 3 fatty acids and α-tocopherol

Authors

  • Sepideh Hosseini Department of Food Science and Technology, Shahr-e-Qods Branch, Islamic Azad University, 374-37541 Tehran, Iran.
  • Somaye Hosseini Plasma Physics Research Centre, Tehran Science and Research Branch, Islamic Azad University, 1477893855 Tehran, Iran.
Abstract:

Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis results indicated that the variability of four responses could be depicted as a quadratic function of ultrasonic processing variables. This investigation revealed that, ultrasound cavitation is a powerful promising approach for controlled production of nanoemulsion with small average droplet size in a range of 94.5 ± 1.14 nm with a polydispersity index of 0.1 ± 0.022 with high α- tocopherol and linolenic acid content which are 851 ± 11.62 mg/L and 43 ± 1.27 mg/L, respectively. This study showed that applying appropriate time and intensity of low frequency ultrasound is considerable importance to maintain the nutritional value of nanoemulsions in bioactive delivery system. 

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Journal title

volume 8  issue 4

pages  351- 360

publication date 2017-10-01

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